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is supported in part by a Banting and Best Diabetes Centre Novo Nordisk Chair in Incretin Biology, and a Sinai Health Novo Nordisk Foundation Fund in Regulatory Peptides

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Of these 9 pairs of sites within glicentin (including glucagon and OXM), GLP-1, and GLP-2, 5 include a site with an amino acid substitution considered to be Deleterious or Affect function, with 1 pair [Gcg residues 73 and 81 (glucagon residues 23 and 29)] having both sites identified as Deleterious and Affect function ( Supplementary Table 9 )